Job Offers

Department of Physiology

Project Description

 

A unique opportunity is available for a candidate interested in working in a multidisciplinary environment applying advanced optical tools in biomedical research at the Perelman School of Medicine, University of Pennsylvania, Philadelphia in the lab of Dr. Melike Lakadamyali. The successful candidate will focus on elucidating nuclear architecture and how it regulates cell fate transitions during somatic cell reprogramming. The successful candidate will use novel optical tools such as single particle tracking and super-resolution microscopy in combination with biochemical and ChIP-Seq assays, to study the role of pioneer factors and nuclear lamina to remodel nanoscale chromatin structure in cells undergoing reprogramming. This project overall will give new insights into how cells determine their fate and therefore allow us to have better control over cell fate determination.   

 

I am looking for highly motivated individuals with experience and background in the fields of chromatin biology, somatic cell reprogramming, iPSCs and ChIP.

 

Experience with optical methods such as single molecule microscopy, computer programming (Matlab, Python and similar), and a strong background in biophysics will be positively evaluated.

 

Deadline: Applications will be regularly reviewed until position is filled.

 

Advisor:

 

Melike Lakadamyali, PhD
Perelman School of Medicine, Department of Physiology

University of Pennsylvania,

Philadelphia, USA

melikel@mail.med.upenn.edu

 

Co-Mentor

 

Maria Pia Cosma

CRG, Barcelona

pia.cosma@crg.edu

 

 

Application

 

Please send CV and letters of reference to melikel@mail.med.upenn.edu

A statement of career goals would be of assistance

 

Penn is an Equal Opportunity/Affirmative Action Employer. They seek candidates who embrace and reflect diversity in the broadest sense.

 

Job offers

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