Job Offers

*Application deadline*
Open until filled

*Context and environment*
Our immunology department includes 10 independent research teams in the fields of basic and applied immunology, working in a very collaborative and international environment. The open position is in line with recent developments and an effort to strengthen the interface between immunology and bioinformatics. It is supported by a competitive LABEX (national call for Laboratory of Excellence) project.

More information:
https://science.institut-curie.org/research/integrated-biology/u932-immu...

*Project*
Dendritic cells (DCs) are key regulators of immune and inflammatory responses. They may play protective or detrimental roles in most infections (viral, bacterial, fungal, protozoal), inflammatory pathologies (including allergy and autoimmunity) and cancers. Because of their central role in immune responses, efforts have been undertaken to harness the potential of DCs and use it in the clinics. The main scientific objective of the project is to apply bioinformatics analysis on in vivo mice models and in vitro human models, to further improve our understanding of the fundamental mechanisms of DC biology.

In close collaborations with wet lab postdocs and students, the selected candidate will design experiments and analyze experimental results obtained by genomics approaches:
- Next-Generation Sequencing data (including ChIP-Seq and RNA-Seq)
- Single-cell RNA-Seq
- Gene and exon expression data (Affymetrix)
- Pathways and Enrichment analyses (Networks, Functional, Transcription Factor Binding Sites…).

The selected candidate will benefit from strong interactions with existing bioinformaticians (10 people) in our department, headed by Sebastian Amigorena.

*Profile*
- Master or PhD bioinformatics, biostatistics or in biology with experience in bioinformatics
- Experience in analysis of large gene expression or NGS datasets
- Experience in use of bioinformatics and bio-statistics tools (R, Bioconductor)
- Programming skills (Bash, Python)
- Knowledge in genomics of human and/or mouse and databases
- Communication in an interdisciplinary research group

*Duration*
A 3-year-COD (French contract dedicated to a specific project) eventually followed by a permanent position depending on success. The salary will depend on profile and experience.

*Salary*
Depending on diploma and experience
This position is highly competitive and only outstanding candidates will be considered. Please send CV and two letters of reference to nicolas.manel@curie.fr

*References*
- Cerboni S … Manel N. Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes. J Exp Med. 2017. doi: 10.1084/jem.20161674.
- Decalf J ... Benaroch P. Sensing of HIV-1 entry triggers a type I interferon response in human primary macrophages. Journal of Virology. 2017. doi: 10.1128/JVI.00147-17.
- Obino D ... Lennon-Duménil AM. Actin nucleation at the centrosome controls lymphocyte polarity. Nature Communications. 2016. doi: 10.1038/ncomms10969.
- Vargas P ... Lennon-Duménil AM. Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells. Nature Cell Biology. 2016. doi: 10.1038/ncb3284.
- Lahaye X ... Manel N. Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication. Cell Reports. 2016. doi: 10.1016/j.celrep.2016.03.074.
- Gentili M … Manel N. Transmission of innate immune signaling by packaging of cGAMP in viral particles. Science. 2015. doi: 10.1126/science.aab3628.
- Raab M, Gentili M ... Lennon-Duménil AM, Manel N, Piel M. ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death. Science. 2016. doi: 10.1126/science.aad7611.